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Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer:A Meta Analysis

《中國醫學科學雜志:英文版》2019年 第3期 | Junpeng Cui Meiyi Lin Zhenghao Liu Baolin Liu   Sixth Department of General Surgery Shengjing Hospital of China Medical University Shenyang 110004 China Department of Rheumatology First Affiliated Hospital of China Medical University Shenyang 110001 China China Medical University Shenyang 110013 China
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摘 要:Objective To clarify the possible association of GSTT1 homozygous deletion with the susceptibility to pancreatic cancer.Methods We searched PubMed database,Chinese Journal Full Text Database(CNKI),and EMBASE to find the eligible studies published up to April 18,2018 for evaluating the relationship between GSTT1 homozygous deletion and pancreatic cancer.The frequency of null genotype for GSTT1 between the pancreatic cancer group and the healthy control group was compared with Chi-square test,and odds ratios(ORs)value and 95%confidence interval(95%CI)were calculated.Results A total of 9 studies met the inclusion criteria,and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis.Compared with the control group,frequency of null genotype for GSTT1 in the pancreatic cancer group was higher(33.4%vs.38.7%,OR=1.26,95%CI=1.01-1.58,P=0.04).Conclusion GSTT1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.
【分 類】【醫藥、衛生】 > 腫瘤學
【關鍵詞】 PANCREATIC cancer gene GSTT1 SUSCEPTIBILITY META analysis
【出 處】 《中國醫學科學雜志:英文版》2019年 第3期 205-210頁 共6頁
【收 錄】 中文科技期刊數據庫
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